Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Pharm Biol
; 50(11): 1423-7, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-22856880
ABSTRACT
CONTEXT The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries. OBJECTIVE:
Our present study investigated the hypouricemic effect of the methanol extract from P. mume fruit (MPMF) in mice with potassium oxonate-induced hyperuremia. MATERIALS ANDMETHODS:
Effect of MPMF (35, 70 and 140 mg/kg, p.o.) administrated for 7 days on the serum, liver, urinary uric acid levels and liver xanthine oxidase (XO) activity were assessed in mice.RESULTS:
Hyperuricemic mice induced by potassium oxonate demonstrated an elevation in serum and liver uric acid levels (11.0 mg/dL and 0.52 mg/g tissue) and a reduction in urinary uric acid levels (49.9 mg/dL). Oral administration of 140 mg/kg MPMF for 7 days reversed the abnormalities in serum, liver and urinary uric acid levels (7.1 mg/dL, 0.37 mg/g tissue and 69.7 mg/dL, respectively). In addition, 70 and 140 mg/kg MPMF (3.1 and 2.9 nmol/min per mg protein) inhibited liver XO activity compared with hyperuricemic mice (3.9 nmol/min per mg protein). DISCUSSION ANDCONCLUSION:
The results indicated that the beneficial hypouricaemic effect of MPMF may be mediated, at least in part, by inhibiting XO activity in the liver. Our study suggests that P. mume and its extracts may have a considerable potential for development as an anti-gout agent for clinical application.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Xanthine Oxidase
/
Plant Extracts
/
Prunus
/
Hyperuricemia
Limits:
Animals
Language:
En
Journal:
Pharm Biol
Year:
2012
Document type:
Article