Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines.

Nishimura, Yukio; Takiguchi, Soichi; Yoshioka, Kiyoko; Nakabeppu, Yusaku; Itoh, Kazuyuki

Nishimura, Yukio; Takiguchi, Soichi; Yoshioka, Kiyoko; Nakabeppu, Yusaku; Itoh, Kazuyuki.

Affiliation

Nishimura Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. ynkio443@gmail.com

Int J Oncol ; 41(4): 1520-30, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22859339

Subject(s)

Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; ErbB Receptors/genetics; Quinazolines/administration & dosage; Sorting Nexins/genetics; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Resistance, Neoplasm/genetics; Endocytosis/drug effects; Endosomes/drug effects; Endosomes/metabolism; ErbB Receptors/biosynthesis; Gefitinib; Gene Expression Regulation, Neoplastic/drug effects; Humans; Lysosomes/drug effects; Lysosomes/metabolism; Phosphorylation/drug effects; RNA, Small Interfering/genetics; Signal Transduction/drug effects; Sorting Nexins/antagonists & inhibitors; Sorting Nexins/biosynthesis

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Carcinoma, Non-Small-Cell Lung / Sorting Nexins / ErbB Receptors Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Japan

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google