Hypertrophic chondrocytes have a limited capacity to cope with increases in endoplasmic reticulum stress without triggering the unfolded protein response.

Kung, Louise H W; Rajpar, M Helen; Briggs, Michael D; Boot-Handford, Raymond P

Kung, Louise H W; Rajpar, M Helen; Briggs, Michael D; Boot-Handford, Raymond P.

Affiliation

Kung LH; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.

J Histochem Cytochem ; 60(10): 734-48, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22859705

Subject(s)

Chondrocytes/physiology; Endoplasmic Reticulum Stress/physiology; Unfolded Protein Response/physiology; Animals; Cell Size; Chondrocytes/cytology; Collagen Type X/genetics; Collagen Type X/metabolism; Embryo, Mammalian; Gene Dosage; Growth Plate/embryology; Growth Plate/metabolism; Hemizygote; Homozygote; Mice; Mice, Mutant Strains; Mutation; Osteochondrodysplasias/genetics; Osteochondrodysplasias/metabolism; Osteochondrodysplasias/pathology; Osteoclasts/physiology; Osteogenesis; Transgenes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chondrocytes / Unfolded Protein Response / Endoplasmic Reticulum Stress Limits: Animals Language: En Journal: J Histochem Cytochem Journal subject: HISTOCITOQUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United States

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