Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.
ACS Chem Neurosci
; 2(8): 433-49, 2011 Aug 17.
Article
in En
| MEDLINE
| ID: mdl-22860170
ABSTRACT
This Review describes recent activity in the advancement of ligands for the metabotropic glutamate 4 receptor subtype and their potential utility as central nervous system (CNS) therapeutics. Until recently, there was a paucity of compounds with suitable selectivity and druglike properties to elucidate the value of this target. The search for selective entities has led several groups to the investigation of allosteric modulators as a path to optimization of potential ligands. Recent efforts, discussed here, have afforded a variety of derivatives with improvements in potency, solubility, and pharmacokinetic properties that garner support for continued investigation and optimization.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System Agents
/
Receptors, Metabotropic Glutamate
/
Drug Discovery
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
ACS Chem Neurosci
Year:
2011
Document type:
Article
Affiliation country:
United States