Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types.
Cell Stem Cell
; 11(2): 147-52, 2012 Aug 03.
Article
in En
| MEDLINE
| ID: mdl-22862941
ABSTRACT
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tissue Donors
/
Histocompatibility Testing
/
Stem Cell Transplantation
/
Induced Pluripotent Stem Cells
/
HLA Antigens
Limits:
Humans
Language:
En
Journal:
Cell Stem Cell
Year:
2012
Document type:
Article
Affiliation country:
United kingdom
Country of publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA