Noninvasive parametric blood flow imaging of head and neck tumours using [15O]H2O and PET/CT.
Nucl Med Commun
; 33(11): 1169-78, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-22863762
ABSTRACT
PURPOSE:
The aim of this study was to develop a simple noninvasive method for measuring blood flow using [15O]H2O PET/CT for the head and neck area applicable in daily clinical practice. PATIENTS ANDMETHODS:
Fifteen dynamic [15O]H2O PET emission scans with simultaneous online radioactivity measurements of radial arterial blood [Blood-input functions (IFs)] were performed. Two noninvasively obtained population-based input functions were calculated by averaging all Blood-IF curves corrected for patients' body mass and injected dose [standardized uptake value (SUV)-IF] and for body surface area (BSA-IF) and injected dose. Parametric perfusion images were calculated for each set of IFs using a linearized two-compartment model, and values for several tissues were compared using Blood-IF as the gold standard.RESULTS:
On comparing all tissues, the correlation between blood flow obtained with the invasive Blood-IF and both SUV-IF and BSA-IF was significant (R2=0.785 with P<0.001 and R2=0.813 with P<0.001, respectively). In individual tissues, the performance of the two noninvasive methods was most reliable in resting muscle and slightly less reliable in tumour and cerebellar regions. In these two tissues, only BSA-IF showed a significant correlation with Blood-IF (R2=0.307 with P=0.032 in tumours and R2=0.398 with P<0.007 in the cerebellum).CONCLUSION:
The BSA-based noninvasive method enables clinically relevant delineation between areas of low and high blood flow in tumours. The blood flow of low-perfusion tissues can be reliably quantified using either of the evaluated noninvasive methods.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Circulation
/
Water
/
Tomography, X-Ray Computed
/
Positron-Emission Tomography
/
Perfusion Imaging
/
Multimodal Imaging
/
Head and Neck Neoplasms
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Nucl Med Commun
Year:
2012
Document type:
Article
Affiliation country:
Finland