Polychromatic decoupling of a manifold of homonuclear scalar interactions in solution-state NMR.

ABSTRACT

Window-acquired tetrachromatic irradiation allows one to decouple simultaneously four amide protons in cyclosporine A (wavy arrows; see figure) leading to simplified multiplets of the alpha protons. By inserting a manifold of polychromatic pulses in each dwell time, several subsystems can be decoupled simultaneously.