Structural framework for covalent inhibition of Clostridium botulinum neurotoxin A by targeting Cys165.

Stura, Enrico A; Le Roux, Laura; Guitot, Karine; Garcia, Sandra; Bregant, Sarah; Beau, Fabrice; Vera, Laura; Collet, Guillaume; Ptchelkine, Denis; Bakirci, Huseyin; Dive, Vincent

Stura, Enrico A; Le Roux, Laura; Guitot, Karine; Garcia, Sandra; Bregant, Sarah; Beau, Fabrice; Vera, Laura; Collet, Guillaume; Ptchelkine, Denis; Bakirci, Huseyin; Dive, Vincent.

Affiliation

Stura EA; Commissariat à l'Energie Atomique, iBiTec-S, Service d'Ingénierie Moléculaire des Protéines, CE-Saclay, 91191 Gif-sur-Yvette, Cedex, France.

J Biol Chem ; 287(40): 33607-14, 2012 Sep 28.

Article in En | MEDLINE | ID: mdl-22869371

Subject(s)

Botulinum Toxins, Type A/antagonists & inhibitors; Clostridium botulinum/metabolism; Cysteine/chemistry; Catalytic Domain; Chemistry, Pharmaceutical/methods; Crystallography, X-Ray/methods; Drug Design; Enzyme Inhibitors/pharmacology; Humans; Kinetics; Mutagenesis, Site-Directed; Peptide Hydrolases/chemistry; Peptides/chemistry; Protein Structure, Tertiary; Recombinant Proteins/chemistry; Synaptosomal-Associated Protein 25/chemistry; Zinc/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clostridium botulinum / Botulinum Toxins, Type A / Cysteine Limits: Humans Language: En Journal: J Biol Chem Year: 2012 Document type: Article Affiliation country: France Country of publication: United States

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