Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.

Hadi, Mackenzie; Chen, Yixi; Starokozhko, Viktoriia; Merema, Marjolijn T; Groothuis, Geny M M

Hadi, Mackenzie; Chen, Yixi; Starokozhko, Viktoriia; Merema, Marjolijn T; Groothuis, Geny M M.

Affiliation

Hadi M; Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Chem Res Toxicol ; 25(9): 1938-47, 2012 Sep 17.

Article in En | MEDLINE | ID: mdl-22870868

Subject(s)

Chemical and Drug Induced Liver Injury/pathology; Animals; Benzodiazepines/chemistry; Benzodiazepines/toxicity; Biomarkers/metabolism; Carbamazepine/chemistry; Carbamazepine/toxicity; Cell Survival/drug effects; Chemical and Drug Induced Liver Injury/metabolism; Chemokines/metabolism; Chromans/chemistry; Chromans/toxicity; Clozapine/chemistry; Clozapine/toxicity; Cytokines/metabolism; Diclofenac/chemistry; Diclofenac/toxicity; Drug Synergism; Female; Glutathione/metabolism; Granulocyte Colony-Stimulating Factor/metabolism; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism; In Vitro Techniques; Ketoconazole/chemistry; Ketoconazole/toxicity; Lipopolysaccharides/toxicity; Mice; Mice, Inbred C57BL; Nitrogen Oxides/metabolism; Olanzapine; Pyrimidines/chemistry; Pyrimidines/toxicity; Thiazolidinediones/chemistry; Thiazolidinediones/toxicity; Triazoles/chemistry; Triazoles/toxicity; Troglitazone; Voriconazole

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemical and Drug Induced Liver Injury Type of study: Prognostic_studies Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United States

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