Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway.

Bosnjak, Zeljko J; Yan, Yasheng; Canfield, Scott; Muravyeva, Maria Y; Kikuchi, Chika; Wells, Clive W; Corbett, John A; Bai, Xiaowen

Bosnjak, Zeljko J; Yan, Yasheng; Canfield, Scott; Muravyeva, Maria Y; Kikuchi, Chika; Wells, Clive W; Corbett, John A; Bai, Xiaowen.

Affiliation

Bosnjak ZJ; Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee, 53226, USA.

Curr Drug Saf ; 7(2): 106-19, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22873495

Subject(s)

Anesthetics, Dissociative/toxicity; Ketamine/toxicity; Neurons/drug effects; Neurotoxicity Syndromes/etiology; Anesthetics, Dissociative/administration & dosage; Antioxidants/administration & dosage; Antioxidants/pharmacology; Apoptosis/drug effects; Cell Differentiation; Chromans/administration & dosage; Chromans/pharmacology; Cytochromes c/metabolism; Dose-Response Relationship, Drug; Embryonic Stem Cells/metabolism; Humans; In Vitro Techniques; Ketamine/administration & dosage; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Mitochondria/metabolism; Neurons/pathology; Oxidative Stress/drug effects; Reactive Oxygen Species/metabolism; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurotoxicity Syndromes / Ketamine / Anesthetics, Dissociative / Neurons Type of study: Prognostic_studies Limits: Humans Language: En Journal: Curr Drug Saf Year: 2012 Document type: Article Affiliation country: United States

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