A comprehensive pathophysiology of dandruff and seborrheic dermatitis - towards a more precise definition of scalp health.
Acta Derm Venereol
; 93(2): 131-7, 2013 Mar 27.
Article
in En
| MEDLINE
| ID: mdl-22875203
ABSTRACT
Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper-proliferative epidermal responses. The objective of this report is to review published literature from in vivo studies of D/SD populations to provide a more complete description of overall scalp health. New biomolecular capabilities establish a depth of pathophysiological understanding not previously achievable with traditional means of investigation. Biomarkers representing inflammation, hyper-proliferation and barrier function are all perturbed by the D/SD condition and robustly respond to therapeutic resolution. These biomarkers can be sampled noninvasively, enabling their use in routine clinical evaluations as either surrogate endpoints or complementary ones to classical signs/symptoms to broaden the etiological learning.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pityriasis
/
Scalp
/
Scalp Dermatoses
/
Dermatitis, Seborrheic
/
Dermatomycoses
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Acta Derm Venereol
Year:
2013
Document type:
Article
Affiliation country:
United States