In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1ß.

Fioravanti, Antonella; Tinti, Laura; Pascarelli, Nicola Antonio; Di Capua, Angela; Lamboglia, Antonello; Cappelli, Andrea; Biava, Mariangela; Giordani, Antonio; Niccolini, Silvia; Galeazzi, Mauro; Anzini, Maurizio

Fioravanti, Antonella; Tinti, Laura; Pascarelli, Nicola Antonio; Di Capua, Angela; Lamboglia, Antonello; Cappelli, Andrea; Biava, Mariangela; Giordani, Antonio; Niccolini, Silvia; Galeazzi, Mauro; Anzini, Maurizio.

Affiliation

Fioravanti A; Department of Clinical Medicine and Immunology, Rheumatology Unit, University of Siena, Italy. fioravanti7@virgilio.it

J Pharmacol Sci ; 120(1): 6-14, 2012.

Article in En | MEDLINE | ID: mdl-22878602

Subject(s)

Chondrocytes/drug effects; Cyclooxygenase 2 Inhibitors/pharmacology; Pyrroles/pharmacology; Sulfones/pharmacology; Aged; Cell Survival/drug effects; Cells, Cultured; Chondrocytes/metabolism; Cyclooxygenase 2/genetics; Dinoprostone/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Humans; Interleukin-1beta/pharmacology; Matrix Metalloproteinase 3/metabolism; Middle Aged; Nitric Oxide/metabolism; Nitric Oxide Synthase Type II/genetics; Osteoarthritis

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Sulfones / Chondrocytes / Cyclooxygenase 2 Inhibitors Limits: Aged / Humans / Middle aged Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: Italy

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