Time and dose-response effects of honokiol on UVB-induced skin cancer development.
Drug Discov Ther
; 6(3): 140-6, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22890204
ABSTRACT
Honokiol has shown chemopreventive effects in chemically-induced and UVB-induced skin cancer in mice. In this investigation, we assessed the time-effects of a topical low dose of honokiol (30 µg), and then the effects of different honokiol doses (30, 45, and 60 µg) on a UVB-induced skin cancer model to find an optimal dose and time for desirable chemopreventive effects. UVB radiation (30 mJ/cm(2), 5 days/week for 25 or 27 weeks) was used to induce skin carcinogenesis in SKH-1 mice. For the time-response experiment 30 µg honokiol in acetone was applied topically to the animals before the UVB exposure (30 min, 1 h, and 2 h) and after the UVB exposure (immediately, 30 min, and 1 h). Control groups were treated with acetone. For the dose-response study, animals were treated topically with acetone or honokiol (30, 45, and 60 µg) one hour before the UVB exposure. In the time-response experiment, honokiol inhibited skin tumor multiplicity by 49-58% while reducing tumor volumes by 70-89%. In the dose-response study, honokiol (30, 45, and 60 µg) significantly decreased skin tumor multiplicity by 36-78% in a dose-dependent manner, while tumor area was reduced by 76-94%. Honokiol (60 µg) significantly reduced tumor incidence by 40% as compared to control group. Honokiol applied in very low doses (30 µg) either before or after UVB radiation shows chemopreventive effects. Honokiol (30, 45, and 60 µg) prevents UVB-induced skin cancer in a dose-dependent manner. Honokiol can be an effective chemopreventive agent against skin cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Biphenyl Compounds
/
Drugs, Chinese Herbal
/
Lignans
/
Neoplasms, Radiation-Induced
/
Antineoplastic Agents, Phytogenic
Limits:
Animals
Language:
En
Journal:
Drug Discov Ther
Year:
2012
Document type:
Article
Affiliation country:
United States
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP