Synthesis and DNA binding properties of 1-(3-aminopropyl)-imidazole-containing triamide f-Im*PyIm: a novel diamino polyamide designed to target 5'-ACGCGT-3'.

Satam, Vijay; Babu, Balaji; Porte, Alexander; Savagian, Mia; Lee, Megan; Smeltzer, Thomas; Liu, Yang; Ramos, Joseph; Wilson, W David; Lin, Shicai; Kiakos, Kostantinos; Hartley, John A; Lee, Moses

Satam, Vijay; Babu, Balaji; Porte, Alexander; Savagian, Mia; Lee, Megan; Smeltzer, Thomas; Liu, Yang; Ramos, Joseph; Wilson, W David; Lin, Shicai; Kiakos, Kostantinos; Hartley, John A; Lee, Moses.

Affiliation

Satam V; Division of Natural & Applied Sciences and Department of Chemistry, Hope College, 35 East, 12th Street, Holland, MI 49423, USA.

Bioorg Med Chem Lett ; 22(18): 5898-902, 2012 Sep 15.

Article in En | MEDLINE | ID: mdl-22892118

Subject(s)

DNA/drug effects; Imidazoles/chemistry; Imidazoles/pharmacology; Propanols/chemistry; Pyrroles/chemistry; Pyrroles/pharmacology; Base Sequence; Binding Sites/drug effects; DNA/chemistry; Imidazoles/chemical synthesis; Molecular Structure; Pyrroles/chemical synthesis; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / DNA / Propanols / Imidazoles Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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