Drusen prevalence and pigmentary changes in Caucasians aged 18-54 years.
Eye (Lond)
; 26(10): 1357-62, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22899005
ABSTRACT
AIMS AND PURPOSE:
The aim of this study was to describe the prevalence and characteristics of drusen and pigmentary changes in a middle-aged population.METHODS:
Retinal images from 500 individuals aged 18-54 years were included. The source of participants was two UK optometry practices. Retinal images were graded using the Wisconsin Age-Related Maculopathy Grading System. However, owing to the relatively young age of the population studied, a new category of drusen of smaller size (<31.5 µm) was introduced.RESULTS:
Drusen were identified within the central macular grid in 91.48% of all gradable eyes and in 444 subjects. Drusen sized <31.5 µm were present in 89.7% of eyes, drusen sized >31.5 µm and <63 µm were present in 45.9% of all eyes and drusen >63 µm and <125 µm were present in only 1.7% of eyes. No eye had drusen larger or equal to 125 µm. Very few eyes (1.2%) showed pigmentary changes within the grid. Drusen load increased with increasing age, P <0.001.CONCLUSIONS:
The frequency of drusen in a younger Caucasian population aged 18-54 years is high, with 91.48% of all gradable eyes having drusen. The most frequent drusen subtype was hard distinct drusen <31.5 µm. No druse greater or equal in size to 125 µm was seen. Pigmentary changes are rare.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinal Drusen
/
White People
/
Retinal Pigment Epithelium
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Eye (Lond)
Journal subject:
OFTALMOLOGIA
Year:
2012
Document type:
Article
Affiliation country:
United kingdom