Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.

Ables, Gene P; Yang, Kryscilla Jian Zhang; Vogel, Silke; Hernandez-Ono, Antonio; Yu, Shuiqing; Yuen, Jason J; Birtles, Susan; Buckett, Linda K; Turnbull, Andrew V; Goldberg, Ira J; Blaner, William S; Huang, Li-Shin; Ginsberg, Henry N

Ables, Gene P; Yang, Kryscilla Jian Zhang; Vogel, Silke; Hernandez-Ono, Antonio; Yu, Shuiqing; Yuen, Jason J; Birtles, Susan; Buckett, Linda K; Turnbull, Andrew V; Goldberg, Ira J; Blaner, William S; Huang, Li-Shin; Ginsberg, Henry N.

Affiliation

Ables GP; Department of Medicine, Columbia University, New York, NY, USA.

J Lipid Res ; 53(11): 2364-79, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22911105

Subject(s)

Chylomicrons/metabolism; Diacylglycerol O-Acyltransferase/deficiency; Diacylglycerol O-Acyltransferase/metabolism; Gastric Emptying/genetics; Postprandial Period/physiology; Triglycerides/metabolism; Animals; Carbamates/pharmacology; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/metabolism; Diacylglycerol O-Acyltransferase/antagonists & inhibitors; Diacylglycerol O-Acyltransferase/genetics; Gastric Emptying/drug effects; Glucagon-Like Peptide 1/blood; Glucagon-Like Peptide-1 Receptor; Indoles/pharmacology; Male; Mice; Mice, Mutant Strains; Peptide Fragments/pharmacology; Postprandial Period/genetics; Receptors, Glucagon/antagonists & inhibitors; Retinoids/metabolism; Triglycerides/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / Chylomicrons / Postprandial Period / Diacylglycerol O-Acyltransferase / Gastric Emptying Limits: Animals Language: En Journal: J Lipid Res Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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