Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.

Juvekar, Ashish; Burga, Laura N; Hu, Hai; Lunsford, Elaine P; Ibrahim, Yasir H; Balmañà, Judith; Rajendran, Anbazhagan; Papa, Antonella; Spencer, Katherine; Lyssiotis, Costas A; Nardella, Caterina; Pandolfi, Pier Paolo; Baselga, José; Scully, Ralph; Asara, John M; Cantley, Lewis C; Wulf, Gerburg M

Juvekar, Ashish; Burga, Laura N; Hu, Hai; Lunsford, Elaine P; Ibrahim, Yasir H; Balmañà, Judith; Rajendran, Anbazhagan; Papa, Antonella; Spencer, Katherine; Lyssiotis, Costas A; Nardella, Caterina; Pandolfi, Pier Paolo; Baselga, José; Scully, Ralph; Asara, John M; Cantley, Lewis C; Wulf, Gerburg M.

Affiliation

Juvekar A; Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Cancer Discov ; 2(11): 1048-63, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22915751

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/enzymology; Genes, BRCA1; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerase Inhibitors; Animals; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors/administration & dosage; Female; Humans; Mice; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Poly(ADP-ribose) Polymerases/genetics; Poly(ADP-ribose) Polymerases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Genes, BRCA1 / Poly(ADP-ribose) Polymerase Inhibitors / Phosphoinositide-3 Kinase Inhibitors Limits: Animals / Female / Humans Language: En Journal: Cancer Discov Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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