SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.

Zhang, Xin; Han, Shu; Kang, Yindong; Guo, Meng; Hong, Shanjuan; Liu, Fang; Fu, Shangxi; Wang, Liming; Wang, Quan-Xing

Zhang, Xin; Han, Shu; Kang, Yindong; Guo, Meng; Hong, Shanjuan; Liu, Fang; Fu, Shangxi; Wang, Liming; Wang, Quan-Xing.

Affiliation

Zhang X; Institute of Organ Transplantation, Changzheng Hospital, Shanghai, China.

Cell Mol Immunol ; 9(5): 390-8, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22922441

Subject(s)

Histone Deacetylase Inhibitors/pharmacology; Hydroxamic Acids/pharmacology; Immunosuppressive Agents/pharmacology; Tacrolimus/pharmacology; Animals; CD4-Positive T-Lymphocytes/metabolism; CTLA-4 Antigen/metabolism; Cell Proliferation; Drug Synergism; Forkhead Transcription Factors/metabolism; Heart Transplantation; Immunosuppressive Agents/therapeutic use; Interleukin-17/immunology; Interleukin-17/metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Tacrolimus/therapeutic use; Transplantation, Homologous/immunology; Vorinostat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tacrolimus / Histone Deacetylase Inhibitors / Hydroxamic Acids / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Mol Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2012 Document type: Article Affiliation country: China Country of publication: China

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