High-dose calcium reduces early-onset hyperkalemia in extremely preterm neonates.
Pediatr Int
; 54(6): 918-22, 2012 Dec.
Article
in En
| MEDLINE
| ID: mdl-22924991
ABSTRACT
BACKGROUND:
Early-onset hyperkalemia often occurs in extremely preterm infants during a few days after birth. While there are several treatments for hyperkalemia, calcium infusion to reduce plasma potassium concentrations remains controversial. The purpose of this study is to investigate whether a high dosage of calcium reduces early-onset hyperkalemia.METHODS:
Extremely low-birthweight neonates born at 22-25 weeks' gestation were enrolled. We analyzed data using multivariate regression analysis and performed a retrospective cohort study with patients divided into two groups according to the dosage of calcium in their initial infusion.RESULTS:
A total of 103 patients were eligible. Early-onset hyperkalemia was observed in 27 patients. The dosage of calcium gluconate during 24 h after birth was the only independent factor affecting early-onset hyperkalemia. The maximum plasma potassium concentration during 72 h after birth was negatively correlated with the dosage of calcium. High-dose calcium reduced occurrences of hyperkalemia and hypoglycemia caused by insulin infusion given for treatment of hyperkalemia, without increasing the risk of any other complications.CONCLUSIONS:
Infusion of calcium gluconate may reduce early-onset hyperkalemia in a dose-dependent manner.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Potassium
/
Calcium Gluconate
/
Calcium
/
Hyperkalemia
/
Infant, Premature, Diseases
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Country/Region as subject:
Asia
Language:
En
Journal:
Pediatr Int
Journal subject:
PEDIATRIA
Year:
2012
Document type:
Article
Affiliation country:
Japan