Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.

Harwood, M D; Neuhoff, S; Carlson, G L; Warhurst, G; Rostami-Hodjegan, A

Harwood, M D; Neuhoff, S; Carlson, G L; Warhurst, G; Rostami-Hodjegan, A.

Affiliation

Harwood MD; Simcyp Ltd a Certara Company, Blades Enterprise Centre, Sheffield, S2 4SU, UK. m.harwood@simcyp.com

Biopharm Drug Dispos ; 34(1): 2-28, 2013 Jan.

Article in En | MEDLINE | ID: mdl-22927116

Subject(s)

Membrane Transport Proteins/metabolism; Models, Biological; Pharmaceutical Preparations/metabolism; Animals; Biological Transport; Drug Design; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Humans; Intestinal Absorption

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Pharmaceutical Preparations / Models, Biological Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biopharm Drug Dispos Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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