Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.

Seo, Kyoung won; Holt, Roseline; Jung, Yong-Sam; Rodriguez, Carlos O; Chen, Xinbin; Rebhun, Robert B

Seo, Kyoung won; Holt, Roseline; Jung, Yong-Sam; Rodriguez, Carlos O; Chen, Xinbin; Rebhun, Robert B.

Affiliation

Seo Kw; Department of Surgical and Radiological Sciences, University of California Davis School of Veterinary Medicine, Davis, California, United States of America.

PLoS One ; 7(8): e42960, 2012.

Article in En | MEDLINE | ID: mdl-22927942

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Ciprofloxacin/pharmacology; Fluoroquinolones/pharmacology; Osteosarcoma/pathology; Animals; CDC2 Protein Kinase/metabolism; Caspase 3/metabolism; Caspase 7/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Dogs; Enrofloxacin; Enzyme Activation/drug effects; G2 Phase Cell Cycle Checkpoints/drug effects; Gene Expression Regulation, Neoplastic/drug effects; M Phase Cell Cycle Checkpoints/drug effects; Phosphorylation/drug effects; S Phase Cell Cycle Checkpoints/drug effects; cdc25 Phosphatases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ciprofloxacin / Osteosarcoma / Apoptosis / Fluoroquinolones / Cell Cycle Checkpoints / Antineoplastic Agents Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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