Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models.

Bougault, Carole; Gosset, Marjolaine; Houard, Xavier; Salvat, Colette; Godmann, Lars; Pap, Thomas; Jacques, Claire; Berenbaum, Francis

Bougault, Carole; Gosset, Marjolaine; Houard, Xavier; Salvat, Colette; Godmann, Lars; Pap, Thomas; Jacques, Claire; Berenbaum, Francis.

Affiliation

Bougault C; University Pierre and Marie Curie Paris VI, Paris, France.

Arthritis Rheum ; 64(12): 3972-81, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22933232

Subject(s)

Carrier Proteins/physiology; Cartilage, Articular/physiopathology; Inflammasomes/physiology; Osteoarthritis, Knee/physiopathology; Stress, Mechanical; Animals; Carrier Proteins/genetics; Caspase 1/metabolism; Cells, Cultured; Chondrocytes/drug effects; Chondrocytes/metabolism; Chondrocytes/pathology; Disease Models, Animal; Humans; Interleukin-1beta/physiology; Lipopolysaccharides/pharmacology; Matrix Metalloproteinases/metabolism; Mice; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Osteoarthritis, Knee/metabolism; Tumor Necrosis Factor-alpha/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Mechanical / Carrier Proteins / Cartilage, Articular / Osteoarthritis, Knee / Inflammasomes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Arthritis Rheum Year: 2012 Document type: Article Affiliation country: France

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