Molecular mechanisms of ursodeoxycholic acid toxicity & side effects: ursodeoxycholic acid freezes regeneration & induces hibernation mode.

Kotb, Magd A

Kotb, Magd A.

Affiliation

Kotb MA; Department of Pediatrics, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo 11956, Egypt.

Int J Mol Sci ; 13(7): 8882-8914, 2012.

Article in En | MEDLINE | ID: mdl-22942741

Subject(s)

Cholagogues and Choleretics/adverse effects; Liver Cirrhosis, Biliary/drug therapy; Liver Regeneration/drug effects; Ursodeoxycholic Acid/adverse effects; Animals; Carcinoma, Hepatocellular/chemically induced; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Cholagogues and Choleretics/therapeutic use; Coenzyme A/metabolism; Cyclic AMP/metabolism; DNA Repair/drug effects; Humans; Liver Cirrhosis, Biliary/metabolism; Liver Cirrhosis, Biliary/pathology; Liver Neoplasms/chemically induced; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Tumor Suppressor Protein p53/metabolism; Ursodeoxycholic Acid/therapeutic use

Key words

PSC; extrahepatic biliary atresia; neonatal cholestasis; neonatal hepatitis; primary biliary cirrhosis; primary sclerosing cholangitis; side effects; toxicity; ursodeoxycholic acid; vanishing bile duct syndrome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ursodeoxycholic Acid / Cholagogues and Choleretics / Liver Cirrhosis, Biliary / Liver Regeneration Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2012 Document type: Article Affiliation country: Egypt

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