Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics.
Expert Rev Clin Pharmacol
; 5(4): 373-88, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22943117
ABSTRACT
Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well tolerated in the treatment of severe chronic hand eczema. This review summarizes the clinical pharmacokinetic and pharmacodynamic data from a number of studies involving alitretinoin. These include the effect of food on the pharmacokinetics of alitretinoin, interactions between alitretinoin and ketoconazole, simvastatin or cyclosporin A, the effect of alitretinoin on the pharmacokinetics of a combined oral contraceptive, alitretinoin in seminal fluid after repeated dosing, and the pharmacokinetics of alitretinoin and its metabolites in a clinical setting.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tretinoin
/
Dermatologic Agents
/
Eczema
Limits:
Animals
/
Humans
Language:
En
Journal:
Expert Rev Clin Pharmacol
Year:
2012
Document type:
Article
Affiliation country:
Switzerland