TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.
Biol Chem
; 393(7): 589-94, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22944662
ABSTRACT
From the earliest stages of embryogenesis and throughout life, transcriptional regulation is carefully orchestrated in order to generate, shape, and reshape the central nervous system (CNS). TAR DNA-binding protein 43 (TDP-43) is identified as a regulator of essential transcriptional events in the CNS. Evidence for its importance comes from the identification of TDP-43 protein aggregates and genetic mutations in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Efforts are being made to learn more about the biological function of TDP-43 and gain a better understanding of its role in neurodegeneration. TDP-43 RNA targets and protein interactions have now been identified, and in vivo evidence shows that TDP-43 is essential in CNS development and function. This review will highlight aspects of these findings.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord
/
Brain
/
Neurodegenerative Diseases
/
DNA-Binding Proteins
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biol Chem
Journal subject:
BIOQUIMICA
Year:
2012
Document type:
Article
Affiliation country:
United States