Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists.

Koller, Manuel; Carcache, David A; Orain, David; Ertl, Peter; Behnke, Dirk; Desrayaud, Sandrine; Laue, Grit; Vranesic, Ivo

Koller, Manuel; Carcache, David A; Orain, David; Ertl, Peter; Behnke, Dirk; Desrayaud, Sandrine; Laue, Grit; Vranesic, Ivo.

Affiliation

Koller M; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, 4002 Basel, Switzerland. koller_manuel@bluewin.ch

Bioorg Med Chem Lett ; 22(20): 6454-9, 2012 Oct 15.

Article in En | MEDLINE | ID: mdl-22963764

Subject(s)

Amides/chemistry; Amides/pharmacology; Pyridones/chemistry; Pyridones/pharmacology; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Allosteric Regulation/drug effects; Drug Discovery; Humans; Inhibitory Concentration 50; Pyrroles/chemistry; Pyrroles/pharmacology; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate/metabolism; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Receptors, Metabotropic Glutamate / Amides Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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