Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.

Vélez de Mendizábal, Nieves; Vásquez-Bahena, Dalia; Jiménez-Andrade, Juan M; Ortiz, Mario I; Castañeda-Hernández, Gilberto; Trocóniz, Iñaki F

Vélez de Mendizábal, Nieves; Vásquez-Bahena, Dalia; Jiménez-Andrade, Juan M; Ortiz, Mario I; Castañeda-Hernández, Gilberto; Trocóniz, Iñaki F.

Affiliation

Vélez de Mendizábal N; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona 31080, Spain.

AAPS J ; 14(4): 904-14, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22968496

Subject(s)

Cyclooxygenase 2 Inhibitors/pharmacology; Diclofenac/analogs & derivatives; Models, Biological; Pain/drug therapy; Animals; Cyclooxygenase 2/drug effects; Cyclooxygenase 2/genetics; Cyclooxygenase 2 Inhibitors/administration & dosage; Diclofenac/administration & dosage; Diclofenac/pharmacology; Disease Models, Animal; Female; Formaldehyde; Injections; Injections, Spinal; Nonlinear Dynamics; Pain/physiopathology; Pain Measurement; Rats; Rats, Wistar; Time Factors; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Diclofenac / Cyclooxygenase 2 Inhibitors / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: AAPS J Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2012 Document type: Article Affiliation country: Spain Country of publication: United States

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