Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.

Cheng, Kui; Wang, Xiaohui; Zhang, Shuting; Yin, Hang

Cheng, Kui; Wang, Xiaohui; Zhang, Shuting; Yin, Hang.

Affiliation

Cheng K; Department of Chemistry and Biochemistry and the BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.

Angew Chem Int Ed Engl ; 51(49): 12246-9, 2012 Dec 03.

Article in En | MEDLINE | ID: mdl-22969053

Subject(s)

Biflavonoids/chemistry; Biflavonoids/pharmacology; Catechin/analogs & derivatives; Toll-Like Receptor 1/antagonists & inhibitors; Toll-Like Receptor 1/chemistry; Toll-Like Receptor 2/antagonists & inhibitors; Toll-Like Receptor 2/chemistry; Animals; Catechin/chemistry; Catechin/pharmacology; Drug Discovery; Macrophages/drug effects; Macrophages/metabolism; Mice; Nitric Oxide/antagonists & inhibitors; Nitric Oxide/biosynthesis; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Biflavonoids / Toll-Like Receptor 1 / Toll-Like Receptor 2 Limits: Animals Language: En Journal: Angew Chem Int Ed Engl Year: 2012 Document type: Article Affiliation country: United States

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