A multiscale, mechanism-driven, dynamic model for the effects of 5&#945;-reductase inhibition on prostate maintenance.

Zager, Michael G; Barton, Hugh A

A multiscale, mechanism-driven, dynamic model for the effects of 5α-reductase inhibition on prostate maintenance.

Zager, Michael G; Barton, Hugh A.

Affiliation

Zager MG; Dynamics and Metabolism, Worldwide Research and Development, Pfizer, Inc, San Diego, California, United States of America. michael.zager@pfizer.com

PLoS One ; 7(9): e44359, 2012.

Article in En | MEDLINE | ID: mdl-22970204

Subject(s)

5-alpha Reductase Inhibitors/pharmacology; Cholestenone 5 alpha-Reductase/metabolism; Models, Biological; Prostate/drug effects; Prostate/enzymology; 5-alpha Reductase Inhibitors/administration & dosage; Animals; Calibration; Dihydrotestosterone/metabolism; Dose-Response Relationship, Drug; Finasteride/administration & dosage; Finasteride/pharmacokinetics; Finasteride/pharmacology; Gene Expression Regulation/drug effects; Humans; Kinetics; Liver/drug effects; Liver/metabolism; Male; Organ Size/drug effects; Organ Size/genetics; Prostate/metabolism; Rats; Testosterone/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostate / Cholestenone 5 alpha-Reductase / 5-alpha Reductase Inhibitors / Models, Biological Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google