Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.

Hoffmann, Brian R; El-Mansy, Mohamed F; Sem, Daniel S; Greene, Andrew S

Hoffmann, Brian R; El-Mansy, Mohamed F; Sem, Daniel S; Greene, Andrew S.

Affiliation

Hoffmann BR; Biotechnology and Bioengineering Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

J Med Chem ; 55(19): 8260-71, 2012 Oct 11.

Article in En | MEDLINE | ID: mdl-22970990

Subject(s)

Hypoglycemic Agents/chemistry; Myocardium/chemistry; Proteome/chemistry; Thiazolidinediones/chemistry; Animals; Chromatography, Affinity; Gluconeogenesis; Glycolysis; Hypoglycemic Agents/toxicity; Ion Channels/chemistry; Ion Channels/metabolism; Lipid Metabolism; Mitochondria/physiology; Myocardium/metabolism; Oxidoreductases/metabolism; Pioglitazone; Protein Binding; Proteome/metabolism; Proteomics; Rats; Rosiglitazone; Synaptic Transmission; Thiazolidinediones/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteome / Thiazolidinediones / Hypoglycemic Agents / Myocardium Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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