Population pharmacokinetics of oxycodone in patients with cancer-related pain.
J Pain Palliat Care Pharmacother
; 26(3): 220-5, 2012 Sep.
Article
in En
| MEDLINE
| ID: mdl-22973910
ABSTRACT
Oxycodone is an opioid widely prescribed to cancer patients for pain relief. However, the pharmacokinetics of oxycodone has not been sufficiently examined. Therefore the aim of this work was to study population pharmacokinetics of oxycodone in patients with cancer pain. The authors analyzed 108 serum oxycodone samples of 33 individuals with nonlinear mixed-effects model (NONMEM). Population pharmacokinetics was calculated using the one-compartment model of clearance, volume of distribution, bioavailability, absorption constant rate, and lag time. An exponential error model was used to determine interindividual variability and a relative error model was applied to assess residual variability. Population pharmacokinetics of oxycodone at the end point were as follows CL(L/h) = 10.7 × [1 + (2 - Child-Pugh Classification)] (Class A = 0, B = 1, C = 2); V(d) (L) = 193; k(a) (h(-1)) = 0.336; T(lag) (h) = 0.859; F (%) = 63.9. Interindividual variability was CL 30.5%, V(d) 44.6%, and F 37.0%, and residual variability was 16.2%. As the total clearance in patients with liver dysfunction (Child-Pugh class B) was reduced to 33.3%, serum concentration of oxycodone increased by 1.5. Therefore, it became clear that dose adjustments are essential when treating patients with liver dysfunction. These findings suggest that population parameters are useful for evaluating pharmacokinetics of oxycodone in patients with cancer pain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxycodone
/
Pain
/
Analgesics, Opioid
/
Models, Biological
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Pain Palliat Care Pharmacother
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2012
Document type:
Article
Affiliation country:
Japan