Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Chaikuad, Apirat; Alfano, Ivan; Kerr, Georgina; Sanvitale, Caroline E; Boergermann, Jan H; Triffitt, James T; von Delft, Frank; Knapp, Stefan; Knaus, Petra; Bullock, Alex N

Chaikuad, Apirat; Alfano, Ivan; Kerr, Georgina; Sanvitale, Caroline E; Boergermann, Jan H; Triffitt, James T; von Delft, Frank; Knapp, Stefan; Knaus, Petra; Bullock, Alex N.

Affiliation

Chaikuad A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, United Kingdom.

J Biol Chem ; 287(44): 36990-8, 2012 Oct 26.

Article in En | MEDLINE | ID: mdl-22977237

Subject(s)

Activin Receptors, Type I/chemistry; Myositis Ossificans/enzymology; Activin Receptors, Type I/antagonists & inhibitors; Activin Receptors, Type I/genetics; Activin Receptors, Type I/metabolism; Amino Acid Motifs; Animals; Bone Morphogenetic Protein 4/physiology; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Luciferases, Firefly/biosynthesis; Luciferases, Firefly/genetics; Mice; Models, Molecular; Mutation, Missense; Myositis Ossificans/genetics; Protein Binding; Pyrazoles/chemistry; Pyrimidines/chemistry; Signal Transduction; Tacrolimus/pharmacology; Tacrolimus Binding Protein 1A/antagonists & inhibitors; Tacrolimus Binding Protein 1A/chemistry; Tacrolimus Binding Protein 1A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Activin Receptors, Type I / Myositis Ossificans Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Document type: Article Affiliation country: United kingdom

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