Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.

Vepsäläinen, Saila; Koivisto, Henna; Pekkarinen, Elina; Mäkinen, Petra; Dobson, Gary; McDougall, Gordon J; Stewart, Derek; Haapasalo, Annakaisa; Karjalainen, Reijo O; Tanila, Heikki; Hiltunen, Mikko

Vepsäläinen, Saila; Koivisto, Henna; Pekkarinen, Elina; Mäkinen, Petra; Dobson, Gary; McDougall, Gordon J; Stewart, Derek; Haapasalo, Annakaisa; Karjalainen, Reijo O; Tanila, Heikki; Hiltunen, Mikko.

Affiliation

Vepsäläinen S; Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.

J Nutr Biochem ; 24(1): 360-70, 2013 Jan.

Article in En | MEDLINE | ID: mdl-22995388

Subject(s)

Alzheimer Disease/drug therapy; Amyloid beta-Protein Precursor/metabolism; Anthocyanins/pharmacology; Plant Extracts/pharmacology; Ribes/chemistry; Vaccinium myrtillus/chemistry; Alzheimer Disease/metabolism; Amyloid Precursor Protein Secretases/metabolism; Animals; Behavior, Animal/drug effects; Brain/drug effects; Brain/metabolism; Cell Line/drug effects; Disease Models, Animal; Flavonoids/pharmacology; Humans; Male; Memory, Short-Term/drug effects; Mice; Mice, Transgenic; Presenilin-1/metabolism; Quercetin/pharmacology; Reactive Oxygen Species/metabolism; Vitamin K 3/toxicity; tau Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Amyloid beta-Protein Precursor / Vaccinium myrtillus / Ribes / Alzheimer Disease / Anthocyanins Limits: Animals / Humans / Male Language: En Journal: J Nutr Biochem Journal subject: BIOQUIMICA / CIENCIAS DA NUTRICAO Year: 2013 Document type: Article Affiliation country: Finland Country of publication: United States

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