TNF-alpha decreases infection-induced lung injury in burn through negative regulation of TLR4/iNOS.

Tsay, Tzyy-Bin; Yang, Ming-Chieh; Chen, Pei-Hsuan; Lin, Cheng-Ta; Hsu, Ching-Mei; Chen, Lee-Wei

Tsay, Tzyy-Bin; Yang, Ming-Chieh; Chen, Pei-Hsuan; Lin, Cheng-Ta; Hsu, Ching-Mei; Chen, Lee-Wei.

Affiliation

Tsay TB; Department of Surgery, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.

J Surg Res ; 179(1): 106-14, 2013 Jan.

Article in En | MEDLINE | ID: mdl-22995661

Subject(s)

Burns/complications; Lung Injury/drug therapy; Lung Injury/etiology; Nitric Oxide Synthase Type II/metabolism; Pseudomonas Infections/complications; Toll-Like Receptor 4/metabolism; Tumor Necrosis Factor-alpha/therapeutic use; Animals; Burns/epidemiology; Comorbidity; Enzyme Inhibitors/therapeutic use; Interleukin-1beta/metabolism; Isothiuronium/analogs & derivatives; Isothiuronium/therapeutic use; Lipopolysaccharides/adverse effects; Lung Injury/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Nitric Oxide Synthase Type II/antagonists & inhibitors; Pseudomonas Infections/epidemiology; Pseudomonas aeruginosa; Receptors, Tumor Necrosis Factor, Type I/deficiency; Receptors, Tumor Necrosis Factor, Type I/genetics; Receptors, Tumor Necrosis Factor, Type I/metabolism; Toll-Like Receptor 4/deficiency; Toll-Like Receptor 4/genetics; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas Infections / Burns / Tumor Necrosis Factor-alpha / Nitric Oxide Synthase Type II / Toll-Like Receptor 4 / Lung Injury Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Surg Res Year: 2013 Document type: Article Affiliation country: Taiwan

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