Frequency of hyponatremia and nonosmolar vasopressin release in the acquired immunodeficiency syndrome.
JAMA
; 263(7): 973-8, 1990 Feb 16.
Article
in En
| MEDLINE
| ID: mdl-2299765
ABSTRACT
The frequency and pathophysiology of hyponatremia were studied in the acquired immunodeficiency syndrome. Of 71 hospitalized patients surveyed retrospectively, hyponatremia was observed in 37 (52%). Of 48 patients studied prospectively, 27 (56%) were hyponatremic. In 16 hyponatremic patients, volume status; serum and urine osmolalities; renal, adrenal, and thyroid function; and plasma vasopressin levels were assessed. Urine osmolalities were inappropriately elevated (mean, 377 mmol/kg of water) relative to serum osmolalities (mean, 268 mmol/kg of water). Four patients had moderate renal insufficiency. Plasma vasopressin levels were elevated in 15 patients, with the highest levels seen in patients who died (median, 7.08 pmol/L). Hyponatremia of multiple etiologies occurred in a majority of inpatients with the acquired immunodeficiency syndrome, often following the administration of hypotonic fluids, and was associated with a 30% (8/27) short-term mortality.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arginine Vasopressin
/
Acquired Immunodeficiency Syndrome
/
Hyponatremia
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
JAMA
Year:
1990
Document type:
Article