Hemangioma, Cavernous, Central Nervous System/metabolism; Hemangioma, Cavernous, Central Nervous System/pathology; Intercellular Junctions/chemistry; Intercellular Junctions/metabolism; Animals; Cardiovascular System/embryology; Cardiovascular System/metabolism; Cardiovascular System/pathology; Cells, Cultured; Disease Models, Animal; Endothelial Cells/chemistry; Endothelial Cells/enzymology; Endothelial Cells/metabolism; Endothelial Cells/pathology; HEK293 Cells; Humans; Intercellular Junctions/enzymology; Intercellular Junctions/pathology; KRIT1 Protein; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/deficiency; Membrane Glycoproteins/genetics; Microtubule-Associated Proteins/chemistry; Microtubule-Associated Proteins/deficiency; Microtubule-Associated Proteins/genetics; Models, Molecular; Protein Conformation; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Signal Transduction; Zebrafish; Zebrafish Proteins/chemistry; Zebrafish Proteins/deficiency; Zebrafish Proteins/genetics; rho-Associated Kinases/antagonists & inhibitors; rho-Associated Kinases/metabolism