The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking.

Kim, Sung Y; Kang, Hyun T; Han, Jeong A; Park, Sang C

Kim, Sung Y; Kang, Hyun T; Han, Jeong A; Park, Sang C.

Affiliation

Kim SY; Department of Biochemistry, Gachon University of Medicine and Science, Incheon, 406-799, South Korea.

Aging Cell ; 11(6): 1102-9, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23013401

Subject(s)

Cell Nucleus/drug effects; Cellular Senescence/genetics; Cytosol/drug effects; Fibroblasts/drug effects; Gene Expression Regulation; Sp1 Transcription Factor/genetics; Animals; Cell Nucleus/metabolism; Cells, Cultured; Cellular Senescence/drug effects; Child; Cytosol/metabolism; Diploidy; Epidermal Growth Factor/pharmacology; Fibroblasts/cytology; Fibroblasts/metabolism; Gene Expression Regulation/drug effects; Gene Knockdown Techniques; Humans; Hydrogen Peroxide/pharmacology; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Protein Transport/drug effects; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Sp1 Transcription Factor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Nucleus / Gene Expression Regulation / Sp1 Transcription Factor / Cellular Senescence / Cytosol / Fibroblasts Type of study: Prognostic_studies Limits: Animals / Child / Humans / Male Language: En Journal: Aging Cell Year: 2012 Document type: Article Affiliation country: South Korea Country of publication: United kingdom

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