Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration.
Thromb Res
; 130 Suppl 1: S98-9, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-23026678
ABSTRACT
Platelets play a major role in hemostasis, but are also involved in vascular biology processes such as angiogenesis and tumor metastasis. Activated platelets release many proteins favoring wound healing and promoting angiogenesis. Microparticles (MP) are small plasma membrane vesicles shed from cells upon their activation or apoptosis. Platelet-derived microparticles (PMP) constitute the majority of the pool of MP circulating in the blood. PMP express and may transfer functional receptors, stimulate the release of cytokines, activate intracellular signaling pathways, promote angiogenesis, and are involved in tissue regeneration and cancer metastasis. We investigated the effect of PMP on cancer cells metastasis and their potential beneficial effect in an ischemic stroke model.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Regeneration
/
Blood Platelets
/
Brain
/
Infarction, Middle Cerebral Artery
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Cell-Derived Microparticles
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Lung Neoplasms
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Thromb Res
Year:
2012
Document type:
Article
Affiliation country:
Israel
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA