Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside.

Kumamoto, Hiroki; Kawahigashi, Sachiko; Wakabayashi, Hiromi; Nakano, Tomohiko; Miyaike, Tomoko; Kitagawa, Yasuyuki; Abe, Hiroshi; Ito, Mika; Haraguchi, Kazuhiro; Balzarini, Jan; Baba, Masanori; Tanaka, Hiromichi

Kumamoto, Hiroki; Kawahigashi, Sachiko; Wakabayashi, Hiromi; Nakano, Tomohiko; Miyaike, Tomoko; Kitagawa, Yasuyuki; Abe, Hiroshi; Ito, Mika; Haraguchi, Kazuhiro; Balzarini, Jan; Baba, Masanori; Tanaka, Hiromichi.

Affiliation

Kumamoto H; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. kumamoto@pharm.showa-u.ac.jp

Chem Commun (Camb) ; 48(89): 10993-5, 2012 Nov 18.

Article in En | MEDLINE | ID: mdl-23038212

Subject(s)

Adenine/analogs & derivatives; Butanes/chemistry; Carbon/chemistry; Fluorine/chemistry; Nucleosides/chemistry; Adenine/chemical synthesis; Adenine/chemistry; Alkenes/chemistry; Butanes/chemical synthesis; Cyclization; Free Radicals; Molecular Structure; Nucleosides/chemical synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Butanes / Carbon / Adenine / Fluorine / Nucleosides Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: Japan

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