5-fluorouracil induced cardiotoxicity: review of the literature.
Cardiol J
; 19(5): 453-8, 2012.
Article
in En
| MEDLINE
| ID: mdl-23042307
ABSTRACT
5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorouracil
/
Heart Diseases
/
Antimetabolites, Antineoplastic
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cardiol J
Year:
2012
Document type:
Article
Affiliation country:
United States