Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones.
Org Biomol Chem
; 10(44): 8814-21, 2012 Nov 28.
Article
in En
| MEDLINE
| ID: mdl-23044781
ABSTRACT
A simple, convenient and efficient metal-free catalyzed oxidative trimeric reaction of indoles toward a variety of 2-(1H-indol-3-yl)-2,3'-biindolin-3-one derivatives in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative homocoupling reaction by using TEMPO in air as an environmentally benign oxidant. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidants
/
Cyclic N-Oxides
/
Biomimetics
/
Indoles
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2012
Document type:
Article