Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

Lekas, Michael; Lekas, Poli; Mei, Shirley H J; Deng, Yupu; Dumont, Daniel J; Stewart, Duncan J

Lekas, Michael; Lekas, Poli; Mei, Shirley H J; Deng, Yupu; Dumont, Daniel J; Stewart, Duncan J.

Affiliation

Lekas M; Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Canada.

PLoS One ; 7(9): e43568, 2012.

Article in En | MEDLINE | ID: mdl-23049737

Subject(s)

Angiopoietin-1/genetics; Angiopoietin-2/genetics; Endothelium, Vascular/metabolism; Hindlimb/blood supply; Ischemia/genetics; Receptor, TIE-2/genetics; Vascular Endothelial Growth Factor A/genetics; Angiopoietin-1/metabolism; Angiopoietin-2/metabolism; Animals; Cytomegalovirus/genetics; Endothelium, Vascular/pathology; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Hindlimb/metabolism; Hindlimb/pathology; Humans; Injections, Intramuscular; Ischemia/metabolism; Ischemia/pathology; Ischemia/therapy; Male; Mice; Mice, Knockout; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptor, TIE-2/agonists; Receptor, TIE-2/antagonists & inhibitors; Receptor, TIE-2/deficiency; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Receptor, TIE-2 / Angiopoietin-1 / Angiopoietin-2 / Vascular Endothelial Growth Factor A / Hindlimb / Ischemia Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Canada

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