Astrocyte-induced synaptogenesis is mediated by transforming growth factor ß signaling through modulation of D-serine levels in cerebral cortex neurons.

Diniz, Luan Pereira; Almeida, Juliana Carvalho; Tortelli, Vanessa; Vargas Lopes, Charles; Setti-Perdigão, Pedro; Stipursky, Joice; Kahn, Suzana Assad; Romão, Luciana Ferreira; de Miranda, Joari; Alves-Leon, Soniza Vieira; de Souza, Jorge Marcondes; Castro, Newton G; Panizzutti, Rogério; Gomes, Flávia Carvalho Alcantara

Diniz, Luan Pereira; Almeida, Juliana Carvalho; Tortelli, Vanessa; Vargas Lopes, Charles; Setti-Perdigão, Pedro; Stipursky, Joice; Kahn, Suzana Assad; Romão, Luciana Ferreira; de Miranda, Joari; Alves-Leon, Soniza Vieira; de Souza, Jorge Marcondes; Castro, Newton G; Panizzutti, Rogério; Gomes, Flávia Carvalho Alcantara.

Affiliation

Diniz LP; Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, Brazil.

J Biol Chem ; 287(49): 41432-45, 2012 Nov 30.

Article in En | MEDLINE | ID: mdl-23055518

Subject(s)

Astrocytes/cytology; Cerebral Cortex/metabolism; Neurons/metabolism; Serine/chemistry; Synapses/metabolism; Transforming Growth Factor beta/metabolism; Animals; Cells, Cultured; Cognition; Culture Media, Conditioned/pharmacology; Electrophysiology; Humans; Mice; Models, Biological; Patch-Clamp Techniques; Signal Transduction; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Synapses / Cerebral Cortex / Astrocytes / Transforming Growth Factor beta / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Document type: Article Affiliation country: Brazil Country of publication: United States

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