Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.
J Clin Invest
; 122(11): 3900-13, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-23064363
ABSTRACT
Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demonstrate that metabolic status and leptin also modify astrocyte-specific glutamate and glucose transporters, indicating that metabolic signals influence synaptic efficacy and glucose uptake and, ultimately, neuronal function. We found that basal and glucose-stimulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered in the offspring of mothers fed a high-fat diet. In adulthood, increased body weight and fasting also altered the expression of glucose and glutamate transporters. These results demonstrate that whole-organism metabolism alters hypothalamic glial cell activity and suggest that these cells play an important role in the pathology of obesity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Fats
/
Astrocytes
/
Leptin
/
Amino Acid Transport System X-AG
/
Glucose Transport Proteins, Facilitative
/
Hypothalamus
/
Obesity
Limits:
Animals
Language:
En
Journal:
J Clin Invest
Year:
2012
Document type:
Article
Affiliation country:
Spain