Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.

Calamaras, Timothy D; Lee, Charlie; Lan, Fan; Ido, Yasuo; Siwik, Deborah A; Colucci, Wilson S

Calamaras, Timothy D; Lee, Charlie; Lan, Fan; Ido, Yasuo; Siwik, Deborah A; Colucci, Wilson S.

Affiliation

Calamaras TD; Myocardial Biology Unit, Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

J Biol Chem ; 287(50): 42400-6, 2012 Dec 07.

Article in En | MEDLINE | ID: mdl-23086944

Subject(s)

Aldehydes/metabolism; Lipoylation/physiology; Protein Processing, Post-Translational/physiology; Protein Serine-Threonine Kinases/metabolism; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; HEK293 Cells; Humans; Lysine/genetics; Lysine/metabolism; Mice; Mutation; Protein Serine-Threonine Kinases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Processing, Post-Translational / Protein Serine-Threonine Kinases / Aldehydes / Lipoylation Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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