Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.

Conforti, Paola; Camnasio, Stefano; Mutti, Cesare; Valenza, Marta; Thompson, Morgan; Fossale, Elisa; Zeitlin, Scott; MacDonald, Marcy E; Zuccato, Chiara; Cattaneo, Elena

Conforti, Paola; Camnasio, Stefano; Mutti, Cesare; Valenza, Marta; Thompson, Morgan; Fossale, Elisa; Zeitlin, Scott; MacDonald, Marcy E; Zuccato, Chiara; Cattaneo, Elena.

Affiliation

Conforti P; Center for Stem Cell Research, Università degli Studi di Milano, Via Balzaretti 9, 20113 Milan, Italy.

Neurobiol Dis ; 50: 160-70, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23089356

Subject(s)

Cell Differentiation/genetics; Nerve Tissue Proteins/metabolism; Neural Stem Cells/cytology; Neuroglia/cytology; Neurons/cytology; Nuclear Proteins/metabolism; Animals; Fluorescent Antibody Technique; Gene Knock-In Techniques; Gene Knockout Techniques; Huntingtin Protein; Huntington Disease/genetics; Mice; Nerve Tissue Proteins/genetics; Neuroglia/metabolism; Neurons/metabolism; Nuclear Proteins/genetics; Peptides; Reverse Transcriptase Polymerase Chain Reaction; Trinucleotide Repeats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Cell Differentiation / Neuroglia / Neural Stem Cells / Nerve Tissue Proteins / Neurons Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United States

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