Genomic expression analyses reveal lysosomal, innate immunity proteins, as disease correlates in murine models of a lysosomal storage disorder.

Alam, Md Suhail; Getz, Michelle; Safeukui, Innocent; Yi, Sue; Tamez, Pamela; Shin, Jenny; Velázquez, Peter; Haldar, Kasturi

Alam, Md Suhail; Getz, Michelle; Safeukui, Innocent; Yi, Sue; Tamez, Pamela; Shin, Jenny; Velázquez, Peter; Haldar, Kasturi.

Affiliation

Alam MS; Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, Indiana, United States of America.

PLoS One ; 7(10): e48273, 2012.

Article in En | MEDLINE | ID: mdl-23094108

Subject(s)

Aging/genetics; Gene Expression; Muramidase/genetics; Niemann-Pick Disease, Type C/genetics; Proteins/genetics; Aging/immunology; Aging/pathology; Animals; Biomarkers/blood; Brain/immunology; Brain/metabolism; Disease Progression; Female; Humans; Immunity, Innate; Intracellular Signaling Peptides and Proteins; Liver/immunology; Liver/metabolism; Lysosomes/genetics; Lysosomes/immunology; Lysosomes/metabolism; Male; Mice; Mice, Knockout; Muramidase/blood; Mutation; Neutrophil Infiltration; Neutrophils/immunology; Neutrophils/metabolism; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C/immunology; Niemann-Pick Disease, Type C/pathology; Proteins/immunology; Proteins/metabolism; Spleen/immunology; Spleen/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Proteins / Muramidase / Gene Expression / Niemann-Pick Disease, Type C Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States

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