In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.

Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie L

Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie L.

Affiliation

Guo J; Molecular Therapeutics and Drug Discovery, The University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Ave, Room G27b, Pittsburgh, PA 15213, USA.

Cancer Chemother Pharmacol ; 71(2): 331-44, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23108699

Subject(s)

Heterocyclic Compounds, 3-Ring/pharmacology; Protein Kinase C/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Thiazepines/pharmacology; Animals; Chromatography, High Pressure Liquid; Female; Heterocyclic Compounds, 3-Ring/metabolism; Humans; Mice; Mice, SCID; Protein Binding; Protein Kinase Inhibitors/metabolism; Tandem Mass Spectrometry; Thiazepines/metabolism; Tissue Distribution; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazepines / Protein Kinase C / Protein Kinase Inhibitors / Heterocyclic Compounds, 3-Ring Limits: Animals / Female / Humans Language: En Journal: Cancer Chemother Pharmacol Year: 2013 Document type: Article Affiliation country: United States Country of publication: Germany

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