Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

van den Wollenberg, Diana J M; Dautzenberg, Iris J C; van den Hengel, Sanne K; Cramer, Steve J; de Groot, Raoul J; Hoeben, Rob C

van den Wollenberg, Diana J M; Dautzenberg, Iris J C; van den Hengel, Sanne K; Cramer, Steve J; de Groot, Raoul J; Hoeben, Rob C.

Affiliation

van den Wollenberg DJ; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

PLoS One ; 7(10): e48064, 2012.

Article in En | MEDLINE | ID: mdl-23110175

Subject(s)

Cell Adhesion Molecules/genetics; Mammalian orthoreovirus 3/genetics; Mutation; Receptors, Cell Surface/genetics; Animals; CHO Cells; Cell Adhesion Molecules/metabolism; Cell Line; Cell Line, Tumor; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors/pharmacology; Glioblastoma/genetics; Glioblastoma/pathology; Glioblastoma/virology; Host Specificity/genetics; Host-Pathogen Interactions/genetics; Humans; Leucine/analogs & derivatives; Leucine/pharmacology; Mammalian orthoreovirus 3/metabolism; Mammalian orthoreovirus 3/physiology; Molecular Sequence Data; Neoplasms/genetics; Neoplasms/pathology; Neoplasms/virology; Oncolytic Virotherapy/methods; Protein Multimerization; Receptors, Cell Surface/metabolism; Receptors, Virus/genetics; Receptors, Virus/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Viral Proteins/chemistry; Viral Proteins/genetics; Viral Proteins/metabolism; Virus Internalization/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mammalian orthoreovirus 3 / Cell Adhesion Molecules / Receptors, Cell Surface / Mutation Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United States

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