Your browser doesn't support javascript.
loading
Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.
Ueda, Yasunori; Mizutani, Chisato; Nannya, Yasuhito; Kurokawa, Mineo; Kobayashi, Sumiko; Takeuchi, Jin; Tamura, Hideto; Ogata, Kiyoyuki; Dan, Kazuo; Shibayama, Hirohiko; Kanakura, Yuzuru; Niimi, Keiko; Sasaki, Ko; Watanabe, Masato; Emi, Nobuhiko; Teramura, Masanao; Motoji, Toshiko; Kida, Michiko; Usuki, Kensuke; Takada, Satoru; Sakura, Toru; Ito, Yoshikazu; Ohyashiki, Kazuma; Ogawa, Hiroyasu; Suzuki, Takahiro; Ozawa, Keiya; Imai, Kiyotoshi; Kasai, Masaharu; Hata, Tomoko; Miyazaki, Yasushi; Morita, Yasuyoshi; Kanamaru, Akihisa; Matsuda, Akira; Tohyama, Kaoru; Koga, Daisuke; Tamaki, Hiroya; Mitani, Kinuko; Naoe, Tomoki; Sugiyama, Haruo; Takaku, Fumimaro.
Affiliation
  • Ueda Y; Department of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan. ueda-y@kchnet.or.jp
Leuk Lymphoma ; 54(7): 1450-8, 2013 Jul.
Article in En | MEDLINE | ID: mdl-23110324
ABSTRACT
A study to evaluate WT1 mRNA expression levels in peripheral blood (PB) and bone marrow aspirate (BM) was conducted in 172 patients, including 115 with myelodysplastic syndromes (MDS), in Japan. The level of WT1 mRNA expression was evaluated according to the French-American-British (FAB) and World Health Organization (WHO) classifications (2001, 2008) and using the International Prognostic Scoring System and the WHO Prognostic Scoring System scales. WT1 mRNA expression levels in PB and BM were well correlated (r = 0.85), and they tended to increase with disease stage progression and in those at higher risk of leukemic transformation. WT1 mRNA expression can be a useful marker for the diagnosis and risk evaluation of MDS.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / RNA, Messenger / Gene Expression / WT1 Proteins Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Document type: Article Affiliation country: Japan
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myelodysplastic Syndromes / RNA, Messenger / Gene Expression / WT1 Proteins Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leuk Lymphoma Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Document type: Article Affiliation country: Japan